In Western countries one in two men and one in three women will develop a malignant tumor during their life. In Germany over 486.000 new cases were diagnosed and over 215.000 patients succumbed to their disease in 2012. Because of the increasing number of senior citizens these numbers are likely to increase further in the coming years. The development of new effective strategies to treat and prevent cancer remains a great challenge.
The Georg-Speyer-Haus, Institute for Tumorbiology and Experimental Therapy, aims to decipher the molecular and cellular basis of tumorigenesis. A particular focus is placed on the analysis and the interaction of various cell types within the tumor, the tumor microenvironment. New therapeutic concepts are being tested in valid pre-clinical tumor models. In close collaboration with the University Cancer Center (UCT) and the LOEWE Center for Cell and Gene Therapy (CGT) as well as as a member of the German Cancer Consortium (DKTK) these concepts are translated into early clinical trials. This translational approach is currently being performed in three different research areas: (I) Cellular Communication in the Stem Cell Niche, (II) Cell-Cell Interaction in the Tumor Stroma and (III) Experimental Therapy. These are supported by various technical Core Facilities.