• GSH C. Arkan
  • PD Dr. Melek Canan Arkan

    T: +4969-63395-600
    Email: Arkan@med.uni-frankfurt.de

     

     

    2018

    Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR.
    Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
    Cell 2018. 174 (1) 88-101.e16.
    PubMed

    2017

    Arkan MC.
    The intricate connection between diet, microbiota, and cancer: A jigsaw puzzle.
    Semin. Immunol. 2017. Sep 1. pii: S1044-5323(17)30023-4.
    PubMed

    2016

    Arkan MC.
    Cancer: Fat and the fate of pancreatic tumours.
    Nature 2016. 536 (7615): 157-8.
    PubMed

    2014

    Schulz MD, Atay C, Heringer J, Romrig FK, Schwitalla S, Aydin B, Ziegler PK, Varga J, Reindl W, Pommerenke C, Salinas-Riester G, Böck A, Alpert C, Blaut M, Polson SC, Brandl L, Kirchner T, Greten FR, Polson SW, Arkan MC.
    High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity.
    Nature 2014. 514 (7523): 508-12.
    PubMed

    Göktuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, Taketo MM, Chariot A, Arkan MC, Greten FR.
    IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells.
    Cell Rep 2014. 7 (6): 1914-25.
    PubMed

    2000-2013

    Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, VandenBerg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M.
    Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice.
    J. Clin. Invest. 2013. 123 (5): 2231-43.
    PubMed

    Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, Greten FR.
    Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.
    Cell 2013. 152 (1-2): 25-38.
    PubMed

    Seleznik GM, Reding T, Romrig F, Saito Y, Mildner A, Segerer S, Sun LK, Regenass S, Lech M, Anders HJ, McHugh D, Kumagi T, Hiasa Y, Lackner C, Haybaeck J, Angst E, Perren A, Balmer ML, Slack E, MacPherson A, Manz MG, Weber A, Browning JL, Arkan MC, Rülicke T, Aguzzi A, Prinz M, Graf R, Heikenwalder M.
    Lymphotoxin β receptor signaling promotes development of autoimmune pancreatitis. Gastroenterology 2012. 143 (5): 1361-74.
    PubMed

    Scheibel M, Klein B, Merkle H, Schulz M, Fritsch R, Greten FR, Arkan MC, Schneider G, Schmid RM. IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo.
    J. Exp. Med. 2010. 207 (12): 2621-30.
    PubMed

    Arkan MC, Greten FR.
    IKK- and NF-κB-mediated functions in carcinogenesis.
    Curr. Top. Microbiol. Immunol. 2011. 349: 159-69.
    PubMed

    Bennecke M, Kriegl L, Bajbouj M, Retzlaff K, Robine S, Jung A, Arkan MC, Kirchner T, Greten FR. Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.
    Cancer Cell 2010. 18 (2): 135-46.
    PubMed

    Khasawneh J, Schulz MD, Walch A, Rozman J, Hrabe de Angelis M, Klingenspor M, Buck A, Schwaiger M, Saur D, Schmid RM, Klöppel G, Sipos B, Greten FR, Arkan MC.
    Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion.
    Proc. Natl. Acad. Sci. U.S.A. 2009. 106 (9): 3354-9.
    Link

    Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, Nebelsiek T, Lundgren-May T, Canli O, Schwitalla S, Matthews V, Schmid RM, Kirchner T, Arkan MC, Ernst M, Greten FR.
    gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.
    Cancer Cell 2009. 15 (2): 91-102.
    PubMed

    Eckmann L, Nebelsiek T, Fingerle AA, Dann SM, Mages J, Lang R, Robine S, Kagnoff MF, Schmid RM, Karin M, Arkan MC, Greten FR.
    Opposing functions of IKKbeta during acute and chronic intestinal inflammation.
    Proc. Natl. Acad. Sci. U.S.A. 2008. 105 (39): 15058-63.
    PubMed

    Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Göktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N, Xu Y, O'Cain T, Jaffee BB, Busch DH, Duyster J, Schmid RM, Eckmann L, Karin M.
    NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.
    Cell 2007. 130 (5): 918-31.
    PubMed

    Lickteig AJ, Slitt AL, Arkan MC, Karin M, Cherrington NJ.
    Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis.
    Drug Metab. Dispos. 2007. 35 (3): 402-9.
    PubMed

    Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M.
    IKK-beta links inflammation to obesity-induced insulin resistance.
    Nat. Med. 2005. 11 (2): 191-8.
    PubMed

    Arkan MC, Leonarduzzi G, Biasi F, Başağa H, Poli G.
    Physiological amounts of ascorbate potentiate phorbol ester-induced nuclear-binding of AP-1 transcription factor in cells of macrophagic lineage.
    Free Radic. Biol. Med. 2001. 31 (3): 374-82.
    PubMed

    Leonarduzzi G, Sevanian A, Sottero B, Arkan MC, Biasi F, Chiarpotto E, Basaga H, Poli G.
    Up-regulation of the fibrogenic cytokine TGF-beta1 by oxysterols: a mechanistic link between cholesterol and atherosclerosis.
    FASEB J. 2001. 15 (9): 1619-21.
    PubMed

    Leonarduzzi G, Arkan MC, Başağa H, Chiarpotto E, Sevanian A, Poli G.
    Lipid oxidation products in cell signaling.
    Free Radic. Biol. Med. 2000. 28 (9): 1370-8.
    PubMed