• GSH F. Greten
  • Prof. Dr. Florian Greten

    T: +4969-63395-232
    Email: Greten@gsh.uni-frankfurt.de


     
     

    2019

    Greten FR, Grivennikov SI.
    Inflammation and Cancer: Triggers, Mechanisms, and Consequences.
    Immunity. 2019 Jul 16;51(1):27-41.
    PubMed

    Ritter B, Greten FR.
    Modulating inflammation for cancer therapy.
    J Exp Med. 2019 Jun 3;216(6):1234-1243.
    PubMed

    De Oliveira T, Ramakrishnan M, Diamanti MA, Ziegler PK, Brombacher F, Greten FR.
    Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic colon carcinogenesis.
    Oncogene. 2019 Mar;38(11):1787-1801.
    PubMed

    2018

    Schulz-Heddergott R, Stark N, Edmunds SJ, Li J, Conradi LC, Bohnenberger H, Ceteci F, Greten FR, Dobbelstein M, Moll UM.
    Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion.
    Cancer Cell. 2018 Aug 13;34(2):298-314.e7.
    PubMed

    Finkelmeier F, Canli Ö, Peiffer KH, Walter D, Tal A, Koch C, Pession U, Vermehren J, Trojan J, Zeuzem S, Piiper A, Greten FR, Grammatikos G, Waidmann O.
    Circulating hypoxia marker carbonic anhydrase IX (CA9) in patients with hepatocellular carcinoma and patients with cirrhosis.

    PLoS One. 2018 Jul 16;13(7):e0200855.
    PubMed

    Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR.
    Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
    Cell. 2018 Jun 11. pii: S0092-8674(18)30640-8.
    PubMed

    Neumann T, Canli Ö, Greten FR.
    Canonical NF-κB signaling in myeloid cells promotes lung metastasis in a mouse breast cancer model.
    Oncotarget. 2018 Mar 30;9(24):16775-16791.
    PubMed

    2017

    Canli Ö, Nikolas AM, Gupta J, Finkelmeier F, Goncharova O, Pesic M, Neumann T, Horst D, Löwer M, Sahin U, Greten FR.
    Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis.
    Cancer Cell. 2017 Dec;32(6):869-883
    Article

    Varga J, Greten FR.
    Cell plasticity in epithelial homeostasis and tumorigenesis.
    Nat Cell Biol. 2017 Oct;19(10):1133-1141. doi: 10.1038/ncb3611.
    PubMed

    Koliaraki V, Pallangyo CK, Greten FR, Kollias G.
    Mesenchymal Cells in Colon Cancer.
    Gastroenterology. 2017 Apr;152(5):964-979. doi: 10.1053/j.gastro.2016.11.049.
    PubMed

    Greten FR.
    Cancer: Tumour stem-cell surprises.
    Nature. 2017 Mar 29;543(7647):626-627. doi: 10.1038/543626a.
    No abstract available.

    Srivatsa S, Paul MC, Cardone C, Holcmann M, Amberg N, Pathria P, Diamanti MA, Linder M, Timelthaler G, Dienes HP, Kenner L, Wrba F, Prager GW, Rose-John S, Eferl R, Liguori G, Botti G, Martinelli E, Greten FR, Ciardiello F, Sibilia M.
    EGFR in Tumor-associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients.
    Gastroenterology. 2017 Apr 8. pii: S0016-5085(17)35414-8. doi:10.1053/j.gastro.2017.03.053.
    PubMed

    Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR.
    IKKα controls ATG16L1 degradation to prevent ER stress during inflammation.
    J Exp Med. 2017 Jan 12. pii: jem.20161867. doi: 10.1084/jem.20161867.
    PubMed

    2016

    Finkelmeier F, Canli Ö, Tal A, Pleli T, Trojan J, Schmidt M, Kronenberger B, Zeuzem S, Piiper A, Greten FR, Waidmann O.
    High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis.
    Eur J Cancer. 2016 May;59:152-9. doi: 10.1016/j.ejca.2016.03.002.
    PubMed

    Greten FR.
    The Irony of Tumor-Induced Inflammation.
    Cell Metab. 2016 Sep 13;24(3):368-9. doi: 10.1016/j.cmet.2016.08.025.
    PubMed

    Pesic M, Greten FR.
    Inflammation and cancer: tissue regeneration gone awry.
    Curr Opin Cell Biol. 2016 Dec;43:55-61. doi: 10.1016/j.ceb.2016.07.010. Review.
    PubMed

    Varga J, Greten FR.
    Lifting the Mist on Gastric Stem Cells.
    Cell Stem Cell. 2016 Jan 7;18(1):7-9. doi: 10.1016/j.stem.2015.12.008.
    PubMed

    2015

    Vogler N, Bocklitz T, Subhi Salah F, Schmidt C, Bräuer R, Cui T, Mireskandari M, Greten FR, Schmitt M, Stallmach A, Petersen I, Popp J.
    Systematic evaluation of the biological variance within the Raman based colorectal tissue diagnostics.
    J Biophotonics. doi: 10.1002/jbio.201500237, 2015.
    PubMed

    PallangyoC, ZieglerP, Greten FR.
    IKKß acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.
    JEM, 212(13):2253-66, 2015.
    PubMed

    Canli Ö, Alankuş YB, Grootjans S, Vegi N, Hültner L, Hoppe PS, Schroeder T, Vandenabeele P, Bornkamm GW, Greten FR.
    Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors.
    Blood, 2015 Oct 13. pii: blood-2015-06-654194.
    PubMed

    Drube S, Weber F, Göpfert C, Loschinski R, Rothe M, Boelke F, Diamanti MA, Löhn T, Ruth J, Schütz D, Häfner N, Greten FR, Stumm R, Hartmann K, Krämer OH, Dudeck A, Kamradt T.
    TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.
    Oncotarget 6(30):28833-50, 2015.
    PubMed

    Drube S, Weber F, Loschinski R, Beyer M, Rothe M, Rabenhorst A, Göpfert C, Meininger I, Diamanti MA, Stegner D, Häfner N, Böttcher M, Reinecke K, Herdegen T, Greten FR, Nieswandt B, Hartmann K, Krämer OH, Kamradt T.
    Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.
    Oncotarget 6:5354-68, 2015.
    PubMed

    Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, Bardella C, Jaeger E, Lewis A, Freeman-Mills L, Giner FC, Rodenas-Cuadrado P, Mallappa S, Clark S, Thomas H, Jeffery R, Poulsom R, Rodriguez-Justo M, Novelli M, Chetty R, Silver A, Sansom OJ, Greten FR, Wang L.M., East J.E., Tomlinson I., Leedham S.
    Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
    Nat Med 21:67-70, 2015.
    PubMed

    2014

    Schulz MD, Atay C, Heringer J, Romrig FK, Schwitalla S, Aydin B, Ziegler PK, Varga J, Reindl W, Pommerenke C, Salinas-Riester G, Böck A, Alpert C, Blaut M, Polson SC, Brandl L, Kirchner T, Greten FR, Polson SW, Arkan MC.
    High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity.
    Nature 514:508-12, 2014.
    PubMed

    Stangl S, Varga J, Freysold B, Traijkovic-Arsic M, Siveke JT, Greten FR, Ntziachristos V, Multhof, G. 
    Selective in vivo imaging of tumors with a tumor cell-specific Hsp70 peptide-based probe.
    Cancer Res 74:6903-12, 2014.
    PubMed

    Varga J, De Oliveira T, Greten FR.
    The architect who never sleeps: Tumor-induced plasticity.
    FEBS Lett 588: 2422-2427, 2014.
    PubMed

    Rokavec M, Oner MG, Li H, Jackstadt R, Jiang L, Lodygin D, Kaller M, Horst D, Ziegler PK, Schwitalla S, Slotta-Huspenina J, Bader FG, Greten FR, Hermeking H.
    IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.
    J Clin Invest 124: 1853-1867, 2014.
    PubMed

    Greten FR.
    YAP1 Takes Over when Oncogenic K-Ras Slumbers.
    Cell 158: 11-12, 2014.
    PubMed

    Goktuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, Taketo MM, Chariot A, Arkan MC, Greten FR.
    IKKalpha promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells.
    Cell Rep 7: 1914-1925, 2014.
    PubMed

    2013

    Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, Lechel A, Rudolph KL, Langer R, Slotta-Huspenina J, Bader FG, Prazeres da Costa O, Neurath MF, Meining A, Kirchner T, Greten FR.
    Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors.
    Cancer Cell 23: 93-106, 2013.
    PubMed

    Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Goktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, Greten FR.
    Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.
    Cell 152: 25-38, 2013.
    PubMed

    Quante M, Varga J, Wang TC, Greten FR.
    The gastrointestinal tumor microenvironment.
    Gastroenterology 145: 63-78, 2013.
    PubMed

    Putoczki TL, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PK, Nguyen PM, Preaudet A, Farid R, Edwards KM, Boglev Y, Luwor RB, Jarnicki A, Horst D, Boussioutas A, Heath JK, Sieber OM, Pleines I, Kile BT, Nash A, Greten FR, McKenzie BS, Ernst M.
    Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.
    Cancer Cell 24: 257-271, 2013.
    PubMed

    Neufert C, Becker C, Tureci O, Waldner MJ, Backert I, Floh K, Atreya I, Leppkes M, Jefremow A, Vieth M, Schneider-Stock R, Klinger P, Greten FR, Threadgill DW, Sahin U, Neurath MF.
    Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK.
    J Clin Invest 123: 1428-1443, 2013.
    PubMed

    Myant KB, Cammareri P, McGhee EJ, Ridgway RA, Huels DJ, Cordero JB, Schwitalla S, Kalna G, Ogg EL, Athineos D, Timpson P, Vidal M, Murray GI, Greten FR, Anderson KI, Sansom OJ.
    ROS production and NF-kappaB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.
    Cell Stem Cell 12: 761-773, 2013.
    PubMed

    Glatz J, Varga J, Garcia-Allende PB, Koch M, Greten FR, Ntziachristos V.
    Concurrent video-rate color and near-infrared fluorescence laparoscopy.
    J Biomed Opt 18: 101302, 2013.
    PubMed

    2011

    Mankan AK, Greten FR.
    Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors.
    Expert Opin Investig Drugs 20: 1263-1275, 2011.
    PubMed

    Mankan AK, Canli O, Schwitalla S, Ziegler P, Tschopp J, Korn T, Greten FR.
    TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis.
    Proc Natl Acad Sci U S A 108: 6567-6572, 2011.
    PubMed

    Kriegl L, Neumann J, Vieth M, Greten FR, Reu S, Jung A, Kirchner T.
    Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer.
    Mod Pathol 24: 1015-1022, 2011.
    PubMed

    Greten FR.
    TAK1: Another mesh in the NF-kappaB - JNK controlled network causing hepatocellular carcinoma.
    J Hepatol 55: 721-723, 2011.
    PubMed

    Fang HY, Greten FR.
    Cell Autonomous and Non-Autonomous Functions of IKKbeta and NF-kappaB during the Pathogenesis of Gastrointestinal Tumors.
    Cancers (Basel) 3: 2214-2222, 2011.
    PubMed

    Arkan MC, Greten FR.
    IKK- and NF-kappaB-mediated functions in carcinogenesis.
    Curr Top Microbiol Immunol 349: 159-169, 2011.
    PubMed

    2010

    Scheibel M, Klein B, Merkle H, Schulz M, Fritsch R, Greten FR, Arkan MC, Schneider G, Schmid RM.
    IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo.
    J Exp Med 207: 2621-2630, 2010.
    PubMed

    Grivennikov SI, Greten FR, Karin M.
    Immunity, inflammation, and cancer.
    Cell 140: 883-899, 2010.
    PubMed

    Greten FR, Karin M.
    Peering into the aftermath: JAKi rips STAT3 in cancer.
    Nat Med 16: 1085-1087, 2010.
    PubMed

    Bennecke M, Kriegl L, Bajbouj M, Retzlaff K, Robine S, Jung A, Arkan MC, Kirchner T, Greten FR.
    Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.
    Cancer Cell 18: 135-146, 2010.
    PubMed

    2009

    Khasawneh J, Schulz MD, Walch A, Rozman J, Hrabe de Angelis M, Klingenspor M, Buck A, Schwaiger M, Saur D, Schmid RM, Kloppel G, Sipos B, Greten FR, Arkan MC.
    Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion.
    Proc Natl Acad Sci U S A 106: 3354-3359, 2009.
    PubMed

    Fang HY, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, Johnson RS, Imityaz HZ, Simon MC, Fredlund E, Greten FR, Rius J, Lewis CE.
    Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia.
    Blood 114: 844-859, 2009.
    PubMed

    Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, Nebelsiek T, Lundgren-May T, Canli O, Schwitalla S, Matthews V, Schmid RM, Kirchner T, Arkan MC, Ernst M, Greten FR.
    gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.
    Cancer Cell 15: 91-102, 2009.
    PubMed

    Bollrath J, Greten FR.
    IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis.
    EMBO Rep 10: 1314-1319, 2009.
    PubMed

    Selected Publications 2001 - 2008

    Eckmann L, Nebelsiek T, Fingerle AA, Dann SM, Mages J, Lang R, Robine S, Kagnoff MF, Schmid RM, Karin M, Arkan MC, Greten FR.
    Opposing functions of IKKbeta during acute and chronic intestinal inflammation.
    Proc Natl Acad Sci U S A 105: 15058-15063, 2008.
    PubMed

    Zaph C, Troy AE, Taylor BC, Berman-Booty LD, Guild KJ, Du Y, Yost EA, Gruber AD, May MJ, Greten FR, Eckmann L, Karin M, Artis D.
    Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis.
    Nature 446: 552-556, 2007.
    PubMed

    Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Goktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N, Xu Y, O'Cain T, Jaffee BB, Busch DH, Duyster J, Schmid RM, Eckmann L, Karin M.
    NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.
    Cell 130: 918-931, 2007.
    PubMed

    Schneider G, Saur D, Siveke JT, Fritsch R, Greten FR, Schmid RM.
    IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression.
    Embo j 25: 3801-3812, 2006.
    PubMed

    Garbe AI, Vermeer B, Gamrekelashvili J, von Wasielewski R, Greten FR, Westendorf AM, Buer J, Schmid RM, Manns MP, Korangy F, Greten TF.
    Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses.
    Cancer Res 66: 508-516, 2006.
    PubMed

    Von Wichert G, Haeussler U, Greten FR, Kliche S, Dralle H, Bohm BO, Adler G, Seufferlein T.
    Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells.
    Oncogene 24: 1284-1289, 2005.
    PubMed

    Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, Karin M.
    Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators.
    Immunity 23: 319-329, 2005.
    PubMed

    Karin M, Greten FR.
    NF-kappaB: linking inflammation and immunity to cancer development and progression.
    Nat Rev Immunol 5: 749-759, 2005.
    PubMed

    Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M.
    IKK-beta links inflammation to obesity-induced insulin resistance.
    Nat Med 11: 191-198, 2005.
    PubMed

    Greten FR, Karin M.
    The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer.
    Cancer Lett 206: 193-199, 2004.
    PubMed

    Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M.
    IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
    Cell 118: 285-296, 2004.
    PubMed

    Egan LJ, Eckmann L, Greten FR, Chae S, Li ZW, Myhre GM, Robine S, Karin M, Kagnoff MF.
    IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium.
    Proc Natl Acad Sci U S A 101: 2452-2457, 2004.
    PubMed

    Schreiner B, Greten FR, Baur DM, Fingerle AA, Zechner U, Bohm C, Schmid M, Hameister H, Schmid RM.
    Murine pancreatic tumor cell line TD2 bears the characteristic pattern of genetic changes with two independently amplified gene loci.
    Oncogene 22: 6802-6809, 2003.
    PubMed

    Schreiner B, Baur DM, Fingerle AA, Zechner U, Greten FR, Adler G, Sipos B, Kloppel G, Hameister H, Schmid RM.
    Pattern of secondary genomic changes in pancreatic tumors of Tgf alpha/Trp53+/- transgenic mice.
    Genes Chromosomes Cancer 38: 240-248, 2003.
    PubMed

    Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M.
    The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion.
    Nat Med 9: 575-581, 2003.
    PubMed

    Wagner M, Weber CK, Bressau F, Greten FR, Stagge V, Ebert M, Leach SD, Adler G, Schmid RM.
    Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells.
    Gastroenterology 122: 1898-1912, 2002.
    PubMed

    Schneider G, Oswald F, Wahl C, Greten FR, Adler G, Schmid RM.
    Cyclosporine inhibits growth through the activating transcription factor/cAMP-responsive element-binding protein binding site in the cyclin D1 promoter.
    J Biol Chem 277: 43599-43607, 2002.
    PubMed

    Park JM, Greten FR, Li ZW, Karin M.
    Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition.
    Science 297: 2048-2051, 2002
    PubMed

    Karin M, Cao Y, Greten FR, Li ZW.
    NF-kappaB in cancer: from innocent bystander to major culprit.
    Nat Rev Cancer 2: 301-310, 2002.
    PubMed

    Greten FR, Weber CK, Greten TF, Schneider G, Wagner M, Adler G, Schmid RM.
    Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis.
    Gastroenterology 123: 2052-2063, 2002.
    PubMed

    Wagner M, Greten FR, Weber CK, Koschnick S, Mattfeldt T, Deppert W, Kern H, Adler G, Schmid RM.
    A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease.
    Genes Dev 15: 286-293, 2001.
    PubMed

    Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M.
    Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway.
    Science 293: 1495-1499, 2001.
    PubMed

    Seitz U, Wagner M, Vogg AT, Glatting G, Neumaier B, Greten FR, Schmid RM, Reske SN.
    In vivo evaluation of 5-[(18)F]fluoro-2'-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model.
    Cancer Res 61: 3853-3857, 2001.
    PubMed

    Greten FR, Wagner M, Weber CK, Zechner U, Adler G, Schmid RM.
    TGF alpha transgenic mice. A model of pancreatic cancer development.
    Pancreatology 1: 363-368, 2001.
    PubMed

    Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M.
    IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.
    Cell 107: 763-775, 2001.
    PubMed