- Über Uns
PhD Student on “Functional Genomics in Colorectal Cancer Organoids”
Our research group is funded by the German Cancer Consortium (DKTK) and investigates the mechanisms that drive progression of colorectal cancer. We have established 3D cellular models (“organoids”) from tumor tissues or by genetic engineering of healthy colonic stem cells using the CRISPR/Cas9 technology (see Michels et al., JEM 2019; Schnalzger et al., EMBO J 2019). To facilitate unbiased and high throughput genetic testing, we are currently developing a platform for pooled barcoded CRISPR/Cas9 library-screening in organoids.
For a research project that is funded by the German Cancer Aid (Krebshilfe) we are now recruiting a highly motivated PhD student. Goal of the project will be to develop organoid-based tools for personalized oncology to identify genetic programs that mediate therapy resistance and synthetic lethality. The student will be trained in 3D cell culture and bioinformatics to further improve and apply our CRISPR/Cas9 organoid platform. Successful candidates will work at the Georg-Speyer-Haus in Frankfurt in a stimulating and collaborative scientific environment. Employer will be the DKFZ that offers excellent opportunities for training and networking.
Requirements are a Master degree in biological sciences and profound experience in cell culture techniques (primary cultures, stem cells or 3D culture) and a solid theoretical background in cancer biology. Previous experiences in next generation sequencing and/or bioinformatic analysis (R-programming) are advantageous. To apply please send an email with your motivation letter, CV, and references/publications demonstrating your previous experience in the above methodologies to email@example.com
The position is available immediately and limited for 18 months with the possibility of extension.
Dr. rer. nat. Henner Farin
Institute for Tumor Biology and Experimental Therapy
Paul-Ehrlich-Str. 42-44 / 60596 Frankfurt / Germany