Postdoctoral position in the laboratory of Dr. Hind Medyouf on Cellular Communication in the Leukemic Stem Cell niche.

The position is based in the laboratory of Dr. Hind Medyouf at the Georg-Speyer-Haus, Institute of Tumor Biology and Experimental Therapy (Frankfurt) and is supported by an ERC-starting grant from the European commission.

The research work in the Medyouf group aims to decipher the molecular and cellular basis of leukemogenesis, with a particular focus on the interaction of various cell types within the bone microenvironment. In this context, new therapeutic concepts are being tested in valid pre-clinical models. The research projects are performed in close collaboration with the University Cancer Center (UCT) and members of the German Cancer Consortium (DKTK) to promote interdisciplinary approaches and rapid translation of our findings into clinical studies.

The specific aim of the project is to understand how (pre)-leukemic cells hijack their microenvironment to reinforce leukemia growth and promote therapy-resistance. To address this question the successful candidate will use state-of-the-art omics approaches and perform functional analysis using a number of disease-relevant model systems newly established in our lab. The project will be carried out in close collaboration with expert clinical partners and features a unique access to primary patients material.

Required qualifications for this position:
Outstanding PhD in biology, biochemistry or equivalent
A minimum of one first author publication in a top tier journal is mandatory
Proven ability to work with animal models
Advanced skills in molecular biology (e.g. CRISPR/Cas9 or other editing techniques; Next generation sequencing)
High motivation to work with mouse models and primary patient samples.
Commitment to work in a highly competitive field.
Full ability to independently drive a research project and analyze complex data
Fluent in written and spoken English, with experience in writing scientific reports/papers.

What we offer:
A highly motivated and dedicated international team.
Innovative projects at the forefront of leukemia research with very high potential for clinical translation.
Top-notch facilities (flow cytometry, Animal facility, small animal imaging platforms, access to sequencing platforms)
Unique access to primary samples
Collaborations with many experimental or theoretical labs in Germany and abroad
A project where your contribution can have a real impact!


Starting date: As soon as possible
Salary: E13 100%, According to TV-H
Duration: Initially for 1 year. Extension possible.
Application deadline: August 15th, 2017.

To apply please send an e-mail with a motivation letter highlighting your previous experience and research interests plus a CV containing a list of publications and references to Medyouf@gsh.uni-frankfurt.de .

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Organoid models to study the colon cancer signaling (Post-doc)

The DKTK Research Group lead by Dr. Henner Farin at the Georg-Speyer-Haus (Frankfurt) is inviting applications for motivated Post-docs to study the colon cancer microenvironment. Human tumor organoids will be characterized by mass spectrometry after in vitro culture and in vivo transplantation to dissect the paracrine crosstalk in colon cancer.

We are searching for a highly motivated post-doctoral fellow for a project that is funded for 2 years by the LOEWE program (excellence initiative of the Hessen State Ministry for Higher Education, Research and the Arts). The researcher will be responsible for generation of new tumor organoid models (CRISPR/Cas9), primary fibroblast co-cultures as well as characterization of a new transgenic mouse model. Transcriptome and proteome profiling will be performed at the Genomics & Proteomics Core Facility (DKFZ in Heidelberg) and in collaboration with our local partners. We offer a highly innovative project and intensive training in a dynamic, international research team.

Requirements are a PhD degree and either practical experiences in proteomics/ protein biochemistry or profound experiences with rodent models (FELASA-B certificate). Expertize in mammalian cell culture (stem cells/ 3D cultures/ primary cells) is mandatory, and interest in bioinformatics (R programming) and a theoretical background in cancer biology are highly desired. Successful candidates should have a goal-oriented work attitude and team working skills.

The position is available for 2 years (with possibility of extension) starting from September 1st, 2017. To apply please send an email with your motivation letter, CV, and references/publications demonstrating your previous experience in the above methodologies until August 1st, 2017 to: Farin@gsh.uni-frankfurt.de

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A Post-Doctoral position in the field of tumor microenvironment and cellular cross-talk in haematological malignancies


The group of Dr. Medyouf is welcoming informal enquiries from talented scientists who would like to undertake a post-doctoral fellowship and have an interest in tumor microenvironment and cellular cross-talk in haematological malignancies. 

Applicants should directly contact Dr Medyouf at:
Medyouf@gsh.uni-frankfurt.de 


 
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A Post-Doctoral position examining aspects of cell plasticity in the tumor microenvironment is currently available in the group of Florian Greten.

Applicants should possess/be expected to obtain a Ph.D. in any of the life sciences or an M.D./Ph.D. degree. We are looking for highly motivated candidates with a strong interest in pursuing an academic career. The candidate for this position should have a strong background in tumor biology and/or immunology and should have experience with mouse models.   

Please send your CV a summary of previous research achievements as well as two letters of recommendation to:
Prof. Dr. Florian Greten
Greten@gsh.uni-frankfurt.de
Georg-Speyer-Haus
Paul-Ehrlich-Straße 42-44
D-60596 Frankfurt